HIV Protein Image May Be the Next Step Toward a Vaccine
A boost to the war against HIV would be to produce an effective vaccine. Over the decades, research has continued to provide promising strategies for disengaging the viral attack on a host. However, much of this research comes to a halt when it comes time to implement the information. The reason for this standstill has to do with the actual physical makeup of the virus. Creating an antibody has proven not to be out of the scientists’ reach, but getting that antibody to stick to the virus has.
Next Step Toward a Vaccine
In order to neutralize the invading virus, the antibody must attach itself. HIV is so well protected that this has proven futile. In an effort to see vulnerabilities in the viral membrane, researchers have tried to get a closer look at some of the external parts that are attached to the membrane. For years, this also seemed out of reach. Many of the proteins that are attached to the virus are delicate and unstable. Attempts at capturing the image resulted in breaking the structure because of its fragile nature. This losing streak, though, just came to an end. Finally, a high-resolution image of a key protein on the outside of the viral wall has been taken. Now, scientists will be able to study the segment and see what approach to take so that antibodies can adequately attach themselves.
This protein is not only a vulnerable part of the virus, but it also happens to be very consistent among various strands of HIV. In other words, it does not mutate as much as other structures. This means that when a vaccine is produced with antibodies that can attach to this protein, it should be able to cover a vast array of HIV infections. There will be no need for multiple vaccines. Also discovered is that while this would be an ideal site to neutralize the virus, there is a shield around it. This sugar-like substance conceals the area and will make contact difficult for antibodies. Taking a closer look at these molecules will help researchers break down the defense so that the immune system can do its job.